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2 edition of prognostic value of CA125 and TPS in epithelial ovarian carcinoma. found in the catalog.

prognostic value of CA125 and TPS in epithelial ovarian carcinoma.

Margaret Briscoe

prognostic value of CA125 and TPS in epithelial ovarian carcinoma.

by Margaret Briscoe

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Published by The Author] in [S.l .
Written in English


Edition Notes

Thesis (M. Sc. (Biomedical Sciences) - University of Ulster, 1994.

The Physical Object
Paginationv, 79, tables :
Number of Pages79
ID Numbers
Open LibraryOL21162629M

  Serum CA is routinely used in the follow up of ovarian cancer. The objective of the present study was to evaluate the usefulness of CA in the detection of ovarian cancer recurrence. This retrospective case study was carried out at a tertiary gynaecological cancer centre in Australia. Patients with all cell types of epithelial ovarian cancer (EOC) treated between and were.   CA is a surface antigen on a high molecular weight glycoprotein recognised by a monoclonal antibody (produced using an ovarian cancer cell line). It is most useful as a marker for non-mucinous ovarian epithelial cancer and indeed is present in up to 80% of cases of advanced ovarian cancer - but is often negative earlier in the disease.

  Purpose The aim of the study was to compare the prognostic value of a response by the Gynecologic Cancer Intergroup (GCIG) Cancer Antigen (CA) response criteria and the Response Evaluation Criteria in Solid Tumors (RECIST) on survival in patients with ovarian carcinoma receiving second-line chemotherapy. Patients and Methods From a single-institution registry of consecutive . Table 2. Serum level of CA and CA of malignant ovarian tumor in various stages and grades (n=75). The mean level of CA in benign ovarian masses was ± U/mL, whereas the mean level of CA in malignant epithelial tumors was ± U/mL, the latter of which was statistically significant (p=).

Preoperative Ca level has been used as a predictor of optimal cytoreduction in advanced ovarian carcinoma. Yet, controversy exists regarding the ability of the tumor marker to predict optimal debulking and moreover of the proper cut-off limit to do so. Clinical Gynecology - edited by Eric J. Bieber April


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Prognostic value of CA125 and TPS in epithelial ovarian carcinoma by Margaret Briscoe Download PDF EPUB FB2

In addition to traditional prognostic factors, a pretreatment serum CEA level ⩾ ng/mL and CA level ⩾ 35 U/mL were also independent prognostic factors for epithelial ovarian cancer. Patients with an elevated CEA and/or CA level before treatment should be considered to be at high-risk of recurrence and : Yu-Han Lin, Chen-Hsuan Wu, Hung-Chun Fu, Yu-Jen Chen, Yin-Yi Chen, Yu-Che Ou, Hao Lin.

Recently, some researchers reported the prognostic value of nadir CA in advanced epithelial ovarian cancer [11, 12, ]. The optimal cutoff level of the nadir CA to predict PFS varies from 10 to 25 U/mL.

There has been no unified consensus about the fixed cut-off nadir value for CACited by: 2. Key Words: ovarian cancer; prognostic factors; CA ; TPS. INTRODUCTION Epithelial ovarian carcinoma is the leading cause of death from gynecological cancer and the fourth most frequent cause of cancer death in women.

Many studies have been devoted to finding prognostic factors that will aid in the development of treatment strategies. The prognostic significance of the half‐life of serum CA in patients responding to chemotherapy for epithelial ovarian carcinoma R. HAWKINS Departments of Medicine and Nuclear Medicine, Royal Marsden Hospital, Fulham Road, London SW3 6JJCited by:   To evaluate the prognostic significance of and predictive value for survival of CA and TPS levels after three chemotherapy courses in ovarian cancer patients.

Methods. We analyzed in a prospective multicenter study the 1- and 2-year overall survival (OS) in ovarian carcinoma by: Prognostic value of CEA, Cyfra and TPS in different subtypes of lung cancer The analysis of survival data of patients with epithelial ovarian cancer proved that both CA and TPS were.

optimal cut-off value of serum CA to predict recurrence var-ied, ranging from 10 to 25 U/mL. Because there are no reports about the value of serum CA levels in patients with advanced epithelial ovarian cancer with complete remission after chemotherapy with paclitaxel ( mg/ m2) and carboplatin (area under the curve of 5) every 3 weeks for.

Abstract. The serum cancer antigen (CA) remains a reliable biomarker in the therapeutic management of epithelial ovarian cancer (EOC). Monitoring the efficacy of cytotoxic chemotherapy (CT) and the early detection of relapse during the follow up of patients in remission represent the two most common clinical situations where the CA has been successfully applied.

Pretreatment values of CEA, CA, SCC and TPS were measured in women with 1) ovarian carcinoma (n = 25), 2) breast cancer (n = 20), 3) endometrial cancer (n =. CA is the gold standard tumor marker in ovarian cancer. Serum level of CA is used to monitor response to chemotherapy, relapse, and disease progression in ovarian cancer patients.

Thus, it is reasonable to investigate whether CA may have utility as a prognostic indicator as well in ovarian cancer. A large number of epidemiological studies have been carried out to this effect.

Specifically, patients with higher CA levels were more likely to experience metastasis to the pleura or nearby costal bone and lung,35 Even though higher CA did not have predictive value in all breast cancer patients; it has been associated with prognosis in patients with recurrent or stage IV breast cancer,34 Elevated CA in.

Objective To assess the prognostic significance of presentation serum albumin, clinical stage and CA levels in ovarian cancer. Design Retrospective analysis of data using a Cox proportional hazards model. Setting A district general hospital oncology unit.

Subject One hundred and fourteen consecutive patients with epithelial ovarian cancer. Overall, approximately 85% of patients with epithelial ovarian cancer have CA levels >35 U/ml.[21, 22] CA is not in and of itself, a good screening test for ovarian cancer because it has a low specificity and positive predictive value.

Most premenopausal patients with elevated CA levels will have benign or physiologic conditions such. In a study of women with epithelial ovarian cancer, Parker and colleagues 30 used surveys to measure knowledge about ovarian cancer, levels of CA preoccupation, depression symptoms, and anxiety symptoms.

Overall, the women, all of whom were undergoing treatment for ovarian cancer, scored low on the knowledge section, which included. Purpose To evaluate the prognostic significance of preoperative CA levels on overall survival of patients with International Federation of Gynecology and Obstetrics (FIGO) stage I epithelial ovarian cancer (EOC).

Patients and Methods Data from patients with FIGO stage I EOC treated in seven gynecologic oncology centers throughout Australia between and were analyzed. Patients. Introduction. Ovarian cancer is the first leading cause of cancer death in female genital malignant tumors.

Approximatelywomen are annually diagnosed with this disease worldwide, and aboutassociated deaths [].The prognosis of epithelial ovarian cancer patients remains poor, which is because of the lack of specific symptoms and the absence of effective early diagnostic.

Prognostic value of CA kinetics and half-life in advanced ovarian cancer. Prospective on ovarian cancer: why prevent. R: Correlation of serum CA with stage, grade and survival of patients with epithelial ovarian cancer at a single centre.

Teeling M, McGing P, Carney DN () The prognostic value of post chemotherapy serum Ca in epithelial ovarian cancer. Ir J Med Sci – PubMed CrossRef Google Scholar. Epithelial ovarian cancer is the fifth most frequent cause of cancer death in women and remains the leading cause of gynecologic cancer‐related deaths in the US and Europe.

1, 2 The mainstay of treatment of advanced ovarian cancer is primary surgery aiming at complete resection followed by platinum and paclitaxel chemotherapy. 3 Until today, no predictors are available indicating which. The Prognostic and Predictive Value of the CA Marker in Lung Cancer Monitoring The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government. CA in ovarian cancer: European Group on Tumor Markers guidelines for clinical use. Int J Gynecol Cancer. Sep-Oct. 15(5) Colombo N, Peiretti M, Parma G, et al. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.Díaz-Padilla I, Razak AR, Minig L, Bernardini MQ, María DCJ.

Prognostic and predictive value of CA in the primary treatment of epithelial ovarian cancer: potentials and pitfalls.

Clin Transl Oncol ; Cohen AD, Piura B, Cohen Y, Shoenfeld Y. [CA in diagnosis and prognosis of epithelial ovarian cancer].Syndicans are another class of secreted extracellular matrix glycoproteins that have an important role in cancer development and prognostic value in various tumours, including ovarian cancer [52,53].

The protein levels of CA and HE4 within blood were significantly elevated in patients with ovarian cancer compared to benign conditions.